Manufacturing Associate – Purification Process Development
Scope of Position:
Individual is involved in the manufacturing of HIV-based vectors and plasmid DNA material under cGMP regulatory requirements, and supporting process development and optimization at scale-up scale. Typically works with bio-hazardous materials. Responsible for performing vector and/or plasmid DNA purification and assay experiments, helping to develop and optimize purification process, writing and reviewing SOP, and laboratory maintenance.
Major Responsibilities:
- Performs and monitors critical manufacturing processes which may be specialized techniques such as various types of filtration, chromatography, column packing, concentration, extraction, centrifugation, bacterial fermentation, Plasmid DNA isolation and purification
- Operates requisite laboratory equipments and instruments such as pumps, tangential flow filtration system, AKTApilot chromatography system, filter integrity tester, spectrophotometer, HPLC and other lab equipment
- Performs analytical procedure, such as ELISA, SDS-PAGE, Western blot, protein assay, PCR, DNA purity analysis, and DNA quantitation
- Maintain accurate laboratory notebook and records
- Writes and reviews Standard Operating Procedures/Manufacturing Procedures
- Complies with current Good Manufacturing Practices regulations
Experience and Qualifications Requisite for Position:
- Experience in manufacturing biological products in an industrial setting is preferred with specific knowledge of chromatographic purification and/or bacterial fermentation and plasmid isolation techniques
- Strong organizational skills and ability to multi-task
- Ability to work effectively in a team environment
Educational Requirements:
B.S. or M.S. in a scientific discipline
If you qualify, let us know by e-mailing your CV and references to: E-mail: employment@virxsys.com.
Back to Careers